Drug interactions
Indomethacin + Sulfamethoxazole
Severity: Minor
Indomethacin and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may modestly raise sulfamethoxazole exposure through reduced elimination or protein-binding displacement. Both drugs can also affect renal function and potassium, so adverse effects may be additive in vulnerable patients.
What this interaction means in plain words
Indomethacin and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion and protein binding displacement; mechanism not firmly established.
What to do
No dose change is usually needed. Monitor renal function and serum potassium when used together in older patients or those with kidney disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Sulfamethoxazole?
MediHelp rates the interaction as minor. Indomethacin and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indomethacin may modestly raise sulfamethoxazole exposure through reduced elimination or protein-binding displacement. Both drugs can also affect renal function and potassium, so adverse effects may be additive in vulnerable patients.
How serious is the interaction between Indomethacin and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor renal function and serum potassium when used together in older patients or those with kidney disease.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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