Drug interactions
Indomethacin + Sulfisoxazole
Severity: Minor
Indomethacin and Sulfisoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may slightly raise sulfisoxazole concentrations through reduced renal elimination or displacement from plasma proteins. Clinical significance is uncertain.
What this interaction means in plain words
Indomethacin and Sulfisoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible protein-binding displacement and renal tubular secretion competition; not firmly established.
What to do
No routine adjustment needed. Monitor for sulfonamide adverse effects and renal function in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Sulfisoxazole?
MediHelp rates the interaction as minor. Indomethacin and Sulfisoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indomethacin may slightly raise sulfisoxazole concentrations through reduced renal elimination or displacement from plasma proteins. Clinical significance is uncertain.
How serious is the interaction between Indomethacin and Sulfisoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed. Monitor for sulfonamide adverse effects and renal function in at-risk patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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