Drug interactions
Indomethacin + Telmisartan-amlodipine
Severity: Moderate
Indomethacin and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can blunt the blood pressure lowering effect of telmisartan and, together with an angiotensin receptor blocker, may impair kidney function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia may also develop.
What this interaction means in plain words
Indomethacin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, and combined with angiotensin II receptor blockade impairs glomerular filtration and potassium handling.
What to do
Prefer an alternative analgesic such as paracetamol where possible; if the NSAID is needed, use the lowest dose for the shortest time and ensure hydration. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Indomethacin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can blunt the blood pressure lowering effect of telmisartan and, together with an angiotensin receptor blocker, may impair kidney function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia may also develop.
How serious is the interaction between Indomethacin and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative analgesic such as paracetamol where possible; if the NSAID is needed, use the lowest dose for the shortest time and ensure hydration. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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