Drug interactions
Indomethacin + Tenofovir df
Severity: Moderate
Indomethacin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by the kidney and can cause proximal tubular injury, while NSAIDs reduce renal perfusion. Concurrent use, particularly with high or repeated NSAID doses, has been associated with acute kidney injury.
What this interaction means in plain words
Indomethacin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from reduced renal prostaglandin-dependent perfusion plus tenofovir tubular toxicity, with shared renal elimination.
What to do
Prefer paracetamol or a non-NSAID alternative; if an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Tenofovir df?
MediHelp rates the interaction as moderate. Indomethacin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by the kidney and can cause proximal tubular injury, while NSAIDs reduce renal perfusion. Concurrent use, particularly with high or repeated NSAID doses, has been associated with acute kidney injury.
How serious is the interaction between Indomethacin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or a non-NSAID alternative; if an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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