Drug interactions
Indomethacin + Ticarcillin
Severity: Minor
Indomethacin and Ticarcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can impair platelet function at high doses, and indomethacin also inhibits platelets and may reduce renal clearance of penicillins. Bleeding risk may be modestly increased.
What this interaction means in plain words
Indomethacin and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive platelet dysfunction, and NSAIDs may compete for renal tubular secretion of penicillins.
What to do
Monitor for bleeding and renal function in patients receiving high-dose ticarcillin with indomethacin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Ticarcillin?
MediHelp rates the interaction as minor. Indomethacin and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticarcillin can impair platelet function at high doses, and indomethacin also inhibits platelets and may reduce renal clearance of penicillins. Bleeding risk may be modestly increased.
How serious is the interaction between Indomethacin and Ticarcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function in patients receiving high-dose ticarcillin with indomethacin.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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