Drug interactions
Indomethacin + Triamcinolone acetonide injectable
Severity: Moderate
Indomethacin and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and NSAID use increases the risk of peptic ulceration and gastrointestinal bleeding. Systemic exposure after injection, particularly intramuscular or repeated dosing, makes this relevant.
What this interaction means in plain words
Indomethacin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury from prostaglandin inhibition by indomethacin and impaired mucosal healing from corticosteroids.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in at-risk patients; counsel on GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Indomethacin and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and NSAID use increases the risk of peptic ulceration and gastrointestinal bleeding. Systemic exposure after injection, particularly intramuscular or repeated dosing, makes this relevant.
How serious is the interaction between Indomethacin and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in at-risk patients; counsel on GI bleeding symptoms.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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