Drug interactions
Indomethacin + Venlafaxine
Severity: Moderate
Indomethacin and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine reduces platelet serotonin content and function, and with indomethacin this increases the likelihood of bleeding, especially from the upper gastrointestinal tract.
What this interaction means in plain words
Indomethacin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and COX-1 inhibition, plus NSAID gastric mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in patients at risk. Prefer a non-NSAID analgesic such as paracetamol when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Indomethacin with Venlafaxine?
MediHelp rates the interaction as moderate. Indomethacin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine reduces platelet serotonin content and function, and with indomethacin this increases the likelihood of bleeding, especially from the upper gastrointestinal tract.
How serious is the interaction between Indomethacin and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in patients at risk. Prefer a non-NSAID analgesic such as paracetamol when feasible.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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