Drug interactions
Indomethacin + Zanubrutinib
Severity: Moderate
Indomethacin and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zanubrutinib is associated with bleeding and cytopenias, and indomethacin impairs platelet function and can cause GI ulceration. Combined use may increase the risk of significant hemorrhage.
What this interaction means in plain words
Indomethacin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Zanubrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet function and hemostasis, with BTK inhibition and NSAID COX-1 inhibition.
What to do
Avoid NSAIDs where possible and use paracetamol; if needed, monitor for bleeding and blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Indomethacin with Zanubrutinib?
MediHelp rates the interaction as moderate. Indomethacin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zanubrutinib is associated with bleeding and cytopenias, and indomethacin impairs platelet function and can cause GI ulceration. Combined use may increase the risk of significant hemorrhage.
How serious is the interaction between Indomethacin and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use paracetamol; if needed, monitor for bleeding and blood counts.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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