Drug interactions
Indomethacin + Zavegepant intranasal
Severity: Minor
Indomethacin and Zavegepant intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zavegepant is an NTCP substrate, and inhibitors of NTCP can raise its systemic exposure. Indomethacin is not an established clinically relevant NTCP inhibitor, so the effect is uncertain and probably small.
What this interaction means in plain words
Indomethacin and Zavegepant intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible NTCP transporter inhibition increasing zavegepant exposure; not well established for indomethacin.
What to do
No dose adjustment is needed; monitor for increased zavegepant adverse effects such as taste disturbance and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Zavegepant intranasal?
MediHelp rates the interaction as minor. Indomethacin and Zavegepant intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zavegepant is an NTCP substrate, and inhibitors of NTCP can raise its systemic exposure. Indomethacin is not an established clinically relevant NTCP inhibitor, so the effect is uncertain and probably small.
How serious is the interaction between Indomethacin and Zavegepant intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for increased zavegepant adverse effects such as taste disturbance and nausea.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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