Drug interactions
Infigratinib + Lapatinib
Severity: Moderate
Infigratinib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is metabolized by CYP3A4, and lapatinib may weakly to moderately inhibit this enzyme. Higher infigratinib levels could worsen toxicities such as hyperphosphatemia, ocular effects and fatigue.
What this interaction means in plain words
Infigratinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by lapatinib reduces infigratinib clearance.
What to do
Monitor for infigratinib adverse effects, including serum phosphate and eye symptoms. Reduce the infigratinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Infigratinib with Lapatinib?
MediHelp rates the interaction as moderate. Infigratinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib is metabolized by CYP3A4, and lapatinib may weakly to moderately inhibit this enzyme. Higher infigratinib levels could worsen toxicities such as hyperphosphatemia, ocular effects and fatigue.
How serious is the interaction between Infigratinib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infigratinib adverse effects, including serum phosphate and eye symptoms. Reduce the infigratinib dose if toxicity develops.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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