Drug interactions
Infigratinib + Nizatidine
Severity: Moderate
Infigratinib and Nizatidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib solubility is pH-dependent, and acid-reducing drugs can lower its absorption, risking reduced anticancer efficacy.
What this interaction means in plain words
Infigratinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nizatidine increases gastric pH, reducing the dissolution and absorption of infigratinib.
What to do
If unavoidable, take infigratinib 2 hours before or 10 hours after nizatidine; avoid proton pump inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Infigratinib with Nizatidine?
MediHelp rates the interaction as moderate. Infigratinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib solubility is pH-dependent, and acid-reducing drugs can lower its absorption, risking reduced anticancer efficacy.
How serious is the interaction between Infigratinib and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, take infigratinib 2 hours before or 10 hours after nizatidine; avoid proton pump inhibitors.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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