Drug interactions
Infigratinib + Sertraline
Severity: Minor
Infigratinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is metabolised mainly by CYP3A4, and sertraline is only a weak CYP3A4 inhibitor. A meaningful increase in infigratinib exposure is therefore unlikely.
What this interaction means in plain words
Infigratinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly reduce infigratinib clearance.
What to do
No dose adjustment is needed. Monitor for infigratinib toxicities such as hyperphosphatemia and eye symptoms as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Infigratinib with Sertraline?
MediHelp rates the interaction as minor. Infigratinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Infigratinib is metabolised mainly by CYP3A4, and sertraline is only a weak CYP3A4 inhibitor. A meaningful increase in infigratinib exposure is therefore unlikely.
How serious is the interaction between Infigratinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for infigratinib toxicities such as hyperphosphatemia and eye symptoms as usual.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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