Drug interactions
Infigratinib + Verapamil
Severity: Moderate
Infigratinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a moderate CYP3A4 inhibitor, may increase infigratinib exposure. This could worsen infigratinib toxicities such as hyperphosphatemia, eye disorders and stomatitis.
What this interaction means in plain words
Infigratinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of infigratinib.
What to do
Prefer an alternative with no CYP3A4 inhibition. If used together, monitor for infigratinib adverse effects and reduce its dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Infigratinib with Verapamil?
MediHelp rates the interaction as moderate. Infigratinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil, a moderate CYP3A4 inhibitor, may increase infigratinib exposure. This could worsen infigratinib toxicities such as hyperphosphatemia, eye disorders and stomatitis.
How serious is the interaction between Infigratinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative with no CYP3A4 inhibition. If used together, monitor for infigratinib adverse effects and reduce its dose if toxicity occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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