Drug interactions
Influenza a vaccine + Pralatrexate
Severity: Moderate
Influenza a vaccine and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pralatrexate may reduce the antibody response to H5N1 influenza vaccine through immune suppression, so protection may be incomplete.
What this interaction means in plain words
Influenza a vaccine and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine-induced immune response.
What to do
Vaccinate before chemotherapy or between cycles where feasible, and do not assume full protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Influenza a vaccine and Pralatrexate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pralatrexate
Frequently asked questions
Can I take Influenza a vaccine with Pralatrexate?
MediHelp rates the interaction as moderate. Influenza a vaccine and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pralatrexate may reduce the antibody response to H5N1 influenza vaccine through immune suppression, so protection may be incomplete.
How serious is the interaction between Influenza a vaccine and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy or between cycles where feasible, and do not assume full protection.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
