Drug interactions
Influenza virus vaccine adjuvanted + Pemetrexed
Severity: Moderate
Influenza virus vaccine adjuvanted and Pemetrexed: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemetrexed may dampen the immune response to adjuvanted H5N1 influenza vaccine because of its immunosuppressive and myelosuppressive effects. Vaccine efficacy may be reduced, though the inactivated vaccine is not unsafe in this setting.
What this interaction means in plain words
Influenza virus vaccine adjuvanted and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine-induced immune response.
What to do
Vaccinate before starting chemotherapy or between cycles if feasible. Consider the patient's exposure risk and that protection may be incomplete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Frequently asked questions
Can I take Influenza virus vaccine adjuvanted with Pemetrexed?
MediHelp rates the interaction as moderate. Influenza virus vaccine adjuvanted and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemetrexed may dampen the immune response to adjuvanted H5N1 influenza vaccine because of its immunosuppressive and myelosuppressive effects. Vaccine efficacy may be reduced, though the inactivated vaccine is not unsafe in this setting.
How serious is the interaction between Influenza virus vaccine adjuvanted and Pemetrexed?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting chemotherapy or between cycles if feasible. Consider the patient's exposure risk and that protection may be incomplete.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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