Drug interactions
Influenza virus vaccine adjuvanted + Pralatrexate
Severity: Moderate
Influenza virus vaccine adjuvanted and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pralatrexate may weaken the immune response to adjuvanted H5N1 vaccine, so protection may be lower than in immunocompetent people.
What this interaction means in plain words
Influenza virus vaccine adjuvanted and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine-induced immune response.
What to do
Vaccinate before starting therapy or between cycles when possible, and consider exposure risk since protection may be incomplete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Frequently asked questions
Can I take Influenza virus vaccine adjuvanted with Pralatrexate?
MediHelp rates the interaction as moderate. Influenza virus vaccine adjuvanted and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pralatrexate may weaken the immune response to adjuvanted H5N1 vaccine, so protection may be lower than in immunocompetent people.
How serious is the interaction between Influenza virus vaccine adjuvanted and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting therapy or between cycles when possible, and consider exposure risk since protection may be incomplete.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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