Drug interactions
Influenza virus vaccine adjuvanted + Prednisone
Severity: Moderate
Influenza virus vaccine adjuvanted and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of prednisone can blunt the antibody response to an adjuvanted H5N1 influenza vaccine, leaving patients less protected.
What this interaction means in plain words
Influenza virus vaccine adjuvanted and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid immunosuppression reduces antibody production after vaccination.
What to do
Vaccinate before starting steroids or at the lowest feasible dose, but do not withhold the vaccine from patients at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Influenza virus vaccine adjuvanted with Prednisone?
MediHelp rates the interaction as moderate. Influenza virus vaccine adjuvanted and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppressive doses of prednisone can blunt the antibody response to an adjuvanted H5N1 influenza vaccine, leaving patients less protected.
How serious is the interaction between Influenza virus vaccine adjuvanted and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting steroids or at the lowest feasible dose, but do not withhold the vaccine from patients at risk.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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