Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Topotecan
Severity: Moderate
Influenza virus vaccine quadrivalent adjuvanted and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy-induced immunosuppression can reduce antibody response to inactivated influenza vaccine. The vaccine is not live, so it is safe, but protection may be diminished.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myelosuppression and lymphocyte depletion from topotecan blunt the vaccine immune response.
What to do
Vaccinate ideally before starting chemotherapy or between cycles away from the nadir; do not withhold annual influenza vaccination in patients on treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Topotecan?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent adjuvanted and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy-induced immunosuppression can reduce antibody response to inactivated influenza vaccine. The vaccine is not live, so it is safe, but protection may be diminished.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before starting chemotherapy or between cycles away from the nadir; do not withhold annual influenza vaccination in patients on treatment.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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