Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Ustekinumab
Severity: Minor
Influenza virus vaccine quadrivalent adjuvanted and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab blocks IL-12/23 signalling and may blunt the antibody response to a non-live influenza vaccine. Vaccination remains safe and recommended, but protection may be lower than in untreated patients.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: IL-12/23 inhibition may modestly reduce immune responses to vaccine antigens.
What to do
Give the inactivated vaccine as scheduled, ideally before starting ustekinumab when feasible, and do not withhold it. Reinforce other preventive measures in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Ustekinumab?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent adjuvanted and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab blocks IL-12/23 signalling and may blunt the antibody response to a non-live influenza vaccine. Vaccination remains safe and recommended, but protection may be lower than in untreated patients.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine as scheduled, ideally before starting ustekinumab when feasible, and do not withhold it. Reinforce other preventive measures in high-risk patients.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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