Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Vinblastine
Severity: Moderate
Influenza virus vaccine quadrivalent adjuvanted and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with vinblastine may reduce the antibody response to inactivated influenza vaccine. The vaccine is not live and is still recommended, so the practical effect is reduced immunogenicity rather than harm.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myelosuppression and immunosuppression from vinblastine impair vaccine immune response.
What to do
Do not withhold the vaccine. Ideally vaccinate before chemotherapy or between cycles when counts are recovering.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Vinblastine?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent adjuvanted and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with vinblastine may reduce the antibody response to inactivated influenza vaccine. The vaccine is not live and is still recommended, so the practical effect is reduced immunogenicity rather than harm.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold the vaccine. Ideally vaccinate before chemotherapy or between cycles when counts are recovering.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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