Drug interactions
Influenza virus vaccine quadrivalent + Procarbazine
Severity: Moderate
Influenza virus vaccine quadrivalent and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a cytotoxic agent that suppresses bone marrow and lymphoid function, so antibody responses to inactivated influenza vaccine may be weaker than normal. Patients may remain inadequately protected despite vaccination.
What this interaction means in plain words
Influenza virus vaccine quadrivalent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression blunts the humoral response to vaccine antigens.
What to do
Give the vaccine at least 2 weeks before starting procarbazine when possible; annual influenza vaccination should still be given during chemotherapy, and consider revaccination after immune recovery if given within 14 days of starting or during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent with Procarbazine?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is a cytotoxic agent that suppresses bone marrow and lymphoid function, so antibody responses to inactivated influenza vaccine may be weaker than normal. Patients may remain inadequately protected despite vaccination.
How serious is the interaction between Influenza virus vaccine quadrivalent and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before starting procarbazine when possible; annual influenza vaccination should still be given during chemotherapy, and consider revaccination after immune recovery if given within 14 days of starting or during therapy.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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