Drug interactions
Influenza virus vaccine trivalent recombinant + Procarbazine
Severity: Moderate
Influenza virus vaccine trivalent recombinant and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine can suppress immune responses, so the recombinant trivalent influenza vaccine may produce lower antibody levels. Patients may stay susceptible to influenza.
What this interaction means in plain words
Influenza virus vaccine trivalent recombinant and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression blunts the humoral response to vaccine antigens.
What to do
Vaccinate at least 2 weeks before starting procarbazine when possible; consider revaccination about 3 months after therapy if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Influenza virus vaccine trivalent recombinant and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent recombinant with Procarbazine?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent recombinant and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine can suppress immune responses, so the recombinant trivalent influenza vaccine may produce lower antibody levels. Patients may stay susceptible to influenza.
How serious is the interaction between Influenza virus vaccine trivalent recombinant and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting procarbazine when possible; consider revaccination about 3 months after therapy if given during treatment.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
