Drug interactions
Inotuzumab + Primaquine
Severity: Major
Inotuzumab and Primaquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin is associated with QT prolongation, and primaquine may add to this effect. The combination may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Inotuzumab and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation.
What to do
Avoid if an alternative exists. If coadministered, monitor ECG and electrolytes before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Inotuzumab with Primaquine?
MediHelp rates the interaction as major. Inotuzumab and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inotuzumab ozogamicin is associated with QT prolongation, and primaquine may add to this effect. The combination may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Inotuzumab and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If coadministered, monitor ECG and electrolytes before and during treatment.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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