Drug interactions
Inotuzumab + Sertraline
Severity: Moderate
Inotuzumab and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin can prolong the QT interval, and sertraline adds a modest effect. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbance.
What this interaction means in plain words
Inotuzumab and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Obtain ECGs and electrolytes at baseline and during treatment. Consider an alternative antidepressant if the QTc increases substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Inotuzumab with Sertraline?
MediHelp rates the interaction as moderate. Inotuzumab and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inotuzumab ozogamicin can prolong the QT interval, and sertraline adds a modest effect. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbance.
How serious is the interaction between Inotuzumab and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs and electrolytes at baseline and during treatment. Consider an alternative antidepressant if the QTc increases substantially.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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