Drug interactions
Insulin aspart + Maprotiline
Severity: Minor
Insulin aspart and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants can alter glucose tolerance, and a modestly increased glucose-lowering effect of insulin may occur. Hypoglycemia awareness may also be affected in some patients.
What this interaction means in plain words
Insulin aspart and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin aspart belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose regulation; not well established.
What to do
Monitor blood glucose more frequently when maprotiline is started, changed or stopped, and adjust the insulin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Maprotiline?
MediHelp rates the interaction as minor. Insulin aspart and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants can alter glucose tolerance, and a modestly increased glucose-lowering effect of insulin may occur. Hypoglycemia awareness may also be affected in some patients.
How serious is the interaction between Insulin aspart and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when maprotiline is started, changed or stopped, and adjust the insulin dose as needed.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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