Drug interactions
Insulin aspart + Tranylcypromine
Severity: Moderate
Insulin aspart and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of insulin, increasing the risk of hypoglycemia. Symptoms may be unpredictable in some patients.
What this interaction means in plain words
Insulin aspart and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
Probable additive glucose lowering; exact mechanism uncertain.
What to do
Monitor blood glucose more frequently when tranylcypromine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Tranylcypromine?
MediHelp rates the interaction as moderate. Insulin aspart and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of insulin, increasing the risk of hypoglycemia. Symptoms may be unpredictable in some patients.
How serious is the interaction between Insulin aspart and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when tranylcypromine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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