Drug interactions
Insulin degludec + Pasireotide
Severity: Major
Insulin degludec and Pasireotide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
What this interaction means in plain words
Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pasireotide suppresses insulin and incretin secretion (GLP-1 and GIP), producing hyperglycemia.
What to do
Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin degludec with Pasireotide?
MediHelp rates the interaction as major. Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
How serious is the interaction between Insulin degludec and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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