Drug interactions
Insulin degludec + Lisinopril
Severity: Moderate
Insulin degludec and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and may enhance the hypoglycemic effect of insulin degludec. Hypoglycemia may occur, particularly after starting the ACE inhibitor.
What this interaction means in plain words
Insulin degludec and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity and raise bradykinin, adding to insulin's glucose-lowering effect.
What to do
Monitor blood glucose more often when starting lisinopril. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Lisinopril?
MediHelp rates the interaction as moderate. Insulin degludec and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and may enhance the hypoglycemic effect of insulin degludec. Hypoglycemia may occur, particularly after starting the ACE inhibitor.
How serious is the interaction between Insulin degludec and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting lisinopril. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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