Drug interactions
Insulin degludec + Nateglinide
Severity: Moderate
Insulin degludec and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide stimulates insulin release from the pancreas, and combining it with insulin raises the risk of hypoglycemia. Combined use is uncommon and offers limited added benefit.
What this interaction means in plain words
Insulin degludec and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect from insulin secretagogue activity combined with exogenous insulin.
What to do
Monitor blood glucose closely and lower the insulin degludec or nateglinide dose if hypoglycemia occurs. Reassess whether both agents are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin degludec with Nateglinide?
MediHelp rates the interaction as moderate. Insulin degludec and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide stimulates insulin release from the pancreas, and combining it with insulin raises the risk of hypoglycemia. Combined use is uncommon and offers limited added benefit.
How serious is the interaction between Insulin degludec and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and lower the insulin degludec or nateglinide dose if hypoglycemia occurs. Reassess whether both agents are needed.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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