Drug interactions
Insulin degludec + Nelfinavir
Severity: Moderate
Insulin degludec and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may cause insulin resistance and hyperglycemia, reducing the effect of insulin degludec. Diabetes control can worsen after starting therapy.
What this interaction means in plain words
Insulin degludec and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced reduction in peripheral insulin sensitivity and possible impaired beta-cell function.
What to do
Monitor glucose and HbA1c after starting nelfinavir and increase the insulin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Insulin degludec with Nelfinavir?
MediHelp rates the interaction as moderate. Insulin degludec and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir may cause insulin resistance and hyperglycemia, reducing the effect of insulin degludec. Diabetes control can worsen after starting therapy.
How serious is the interaction between Insulin degludec and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting nelfinavir and increase the insulin dose if needed.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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