Drug interactions
Insulin degludec + Ramipril
Severity: Moderate
Insulin degludec and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin, leading to hypoglycemia in some patients. The effect is most noticeable early after starting the ACE inhibitor.
What this interaction means in plain words
Insulin degludec and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Ramipril belongs to Cardiovascular.
Why it happens
Additive glucose lowering, with ACE inhibition improving insulin sensitivity.
What to do
Monitor blood glucose more frequently when starting or adjusting ramipril, and lower the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Ramipril?
MediHelp rates the interaction as moderate. Insulin degludec and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin, leading to hypoglycemia in some patients. The effect is most noticeable early after starting the ACE inhibitor.
How serious is the interaction between Insulin degludec and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or adjusting ramipril, and lower the insulin dose if hypoglycemia occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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