Drug interactions
Insulin degludec + Somatrogon
Severity: Moderate
Insulin degludec and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a long-acting growth hormone, reduces insulin sensitivity and can raise blood glucose, increasing insulin needs.
What this interaction means in plain words
Insulin degludec and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone antagonizes insulin action, causing insulin resistance.
What to do
Monitor glucose when starting or adjusting somatrogon and titrate insulin degludec as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Insulin degludec with Somatrogon?
MediHelp rates the interaction as moderate. Insulin degludec and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a long-acting growth hormone, reduces insulin sensitivity and can raise blood glucose, increasing insulin needs.
How serious is the interaction between Insulin degludec and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or adjusting somatrogon and titrate insulin degludec as needed.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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