Drug interactions
Insulin degludec + Trandolapril
Severity: Moderate
Insulin degludec and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and may potentiate insulin-induced hypoglycemia. The effect is most notable after starting the ACE inhibitor.
What this interaction means in plain words
Insulin degludec and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive glucose lowering through enhanced insulin sensitivity with ACE inhibition.
What to do
Monitor blood glucose more frequently when starting or changing trandolapril and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Trandolapril?
MediHelp rates the interaction as moderate. Insulin degludec and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and may potentiate insulin-induced hypoglycemia. The effect is most notable after starting the ACE inhibitor.
How serious is the interaction between Insulin degludec and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing trandolapril and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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