Drug interactions
Insulin degludec / insulin aspart + Irbesartan
Severity: Moderate
Insulin degludec / insulin aspart and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and enhance the glucose lowering of insulin. Hypoglycemia may occur, particularly after starting the ARB.
What this interaction means in plain words
Insulin degludec / insulin aspart and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible improved insulin sensitivity from angiotensin receptor blockade adds to insulin action.
What to do
Monitor blood glucose more frequently when starting or stopping irbesartan. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Irbesartan?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity and enhance the glucose lowering of insulin. Hypoglycemia may occur, particularly after starting the ARB.
How serious is the interaction between Insulin degludec / insulin aspart and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping irbesartan. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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