Drug interactions
Insulin degludec / insulin aspart + Nadolol
Severity: Moderate
Insulin degludec / insulin aspart and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol may mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and can prolong recovery from low glucose. It may also alter glycemic control in either direction.
What this interaction means in plain words
Insulin degludec / insulin aspart and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Non-selective beta-blockade blunts adrenergic hypoglycemia symptoms and impairs glycogenolytic recovery.
What to do
Monitor blood glucose more frequently and educate the patient that sweating may be the main remaining warning sign. Adjust insulin doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Nadolol?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol may mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and can prolong recovery from low glucose. It may also alter glycemic control in either direction.
How serious is the interaction between Insulin degludec / insulin aspart and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and educate the patient that sweating may be the main remaining warning sign. Adjust insulin doses as needed.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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