Drug interactions
Insulin degludec / insulin aspart + Nebivolol
Severity: Moderate
Insulin degludec / insulin aspart and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and may delay recovery from low glucose. They can also alter glycemic control in either direction. Sweating is usually preserved.
What this interaction means in plain words
Insulin degludec / insulin aspart and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade blunts hypoglycemia symptoms and impairs glycogenolytic recovery.
What to do
Monitor blood glucose more frequently after starting or changing nebivolol and educate patients that hypoglycemia may present with sweating rather than palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Nebivolol?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning signs of hypoglycemia such as tremor and tachycardia, and may delay recovery from low glucose. They can also alter glycemic control in either direction. Sweating is usually preserved.
How serious is the interaction between Insulin degludec / insulin aspart and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting or changing nebivolol and educate patients that hypoglycemia may present with sweating rather than palpitations.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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