Drug interactions
Insulin degludec / insulin aspart + Quetiapine
Severity: Moderate
Insulin degludec / insulin aspart and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can worsen glucose tolerance and cause hyperglycemia, weight gain and dyslipidemia, which may reduce the effectiveness of insulin therapy. Insulin requirements may rise after quetiapine is started.
What this interaction means in plain words
Insulin degludec / insulin aspart and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quetiapine-related insulin resistance and impaired glucose regulation, which opposes the glucose-lowering effect of insulin.
What to do
Monitor blood glucose more often when starting or changing quetiapine and adjust the insulin dose as needed. Watch for hypoglycemia if quetiapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Quetiapine?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can worsen glucose tolerance and cause hyperglycemia, weight gain and dyslipidemia, which may reduce the effectiveness of insulin therapy. Insulin requirements may rise after quetiapine is started.
How serious is the interaction between Insulin degludec / insulin aspart and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or changing quetiapine and adjust the insulin dose as needed. Watch for hypoglycemia if quetiapine is stopped.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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