Drug interactions
Insulin degludec / insulin aspart + Saxagliptin-metformin
Severity: Moderate
Insulin degludec / insulin aspart and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with saxagliptin and metformin produces additive glucose lowering and increases the risk of hypoglycemia. This is a common intended combination but often requires insulin dose reduction.
What this interaction means in plain words
Insulin degludec / insulin aspart and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effects.
What to do
Monitor blood glucose frequently when starting or adjusting therapy and reduce the insulin dose if hypoglycemia occurs. Educate patients on hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with saxagliptin and metformin produces additive glucose lowering and increases the risk of hypoglycemia. This is a common intended combination but often requires insulin dose reduction.
How serious is the interaction between Insulin degludec / insulin aspart and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting or adjusting therapy and reduce the insulin dose if hypoglycemia occurs. Educate patients on hypoglycemia recognition.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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