Drug interactions
Insulin degludec / insulin aspart + Tolazamide
Severity: Moderate
Insulin degludec / insulin aspart and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sulfonylurea with insulin gives additive glucose lowering and increases the risk of hypoglycemia. The combination is often used deliberately but needs dose coordination.
What this interaction means in plain words
Insulin degludec / insulin aspart and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of exogenous insulin and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor blood glucose frequently when starting, adjusting or stopping either agent. Reduce the insulin or tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Tolazamide?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sulfonylurea with insulin gives additive glucose lowering and increases the risk of hypoglycemia. The combination is often used deliberately but needs dose coordination.
How serious is the interaction between Insulin degludec / insulin aspart and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting, adjusting or stopping either agent. Reduce the insulin or tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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