Drug interactions
Insulin degludec / insulin aspart + Tranylcypromine
Severity: Moderate
Insulin degludec / insulin aspart and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of insulin and may increase the risk of hypoglycemia. This may require dose reduction of insulin.
What this interaction means in plain words
Insulin degludec / insulin aspart and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive blood glucose lowering; MAO inhibitors may enhance insulin sensitivity or hypoglycemic response.
What to do
Monitor blood glucose more frequently when starting or stopping tranylcypromine. Adjust insulin doses as needed and counsel the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Tranylcypromine?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of insulin and may increase the risk of hypoglycemia. This may require dose reduction of insulin.
How serious is the interaction between Insulin degludec / insulin aspart and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping tranylcypromine. Adjust insulin doses as needed and counsel the patient about hypoglycemia symptoms.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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