Drug interactions
Insulin degludec-liraglutide + Insulin glulisine
Severity: Moderate
Insulin degludec-liraglutide and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding prandial insulin to a basal insulin and GLP-1 agonist combination increases the glucose-lowering effect and the risk of hypoglycemia. This is a recognized regimen but needs dose titration.
What this interaction means in plain words
Insulin degludec-liraglutide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Insulin glulisine belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effect of insulin and GLP-1 receptor agonism.
What to do
Titrate doses on the basis of glucose monitoring and reduce the insulin glulisine dose if hypoglycemia occurs. Review total insulin dose when starting or stopping the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin degludec-liraglutide with Insulin glulisine?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding prandial insulin to a basal insulin and GLP-1 agonist combination increases the glucose-lowering effect and the risk of hypoglycemia. This is a recognized regimen but needs dose titration.
How serious is the interaction between Insulin degludec-liraglutide and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses on the basis of glucose monitoring and reduce the insulin glulisine dose if hypoglycemia occurs. Review total insulin dose when starting or stopping the combination.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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