Drug interactions
Insulin degludec-liraglutide + Isocarboxazid
Severity: Moderate
Insulin degludec-liraglutide and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors can enhance the blood glucose lowering action of insulin and other antidiabetic drugs. Combining isocarboxazid with this product may lead to unexpected or prolonged hypoglycemia.
What this interaction means in plain words
Insulin degludec-liraglutide and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibitors may enhance insulin secretion and sensitivity, adding to the hypoglycemic effect of insulin and liraglutide.
What to do
Check blood glucose more often when isocarboxazid is started or stopped, and lower the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Insulin degludec-liraglutide with Isocarboxazid?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors can enhance the blood glucose lowering action of insulin and other antidiabetic drugs. Combining isocarboxazid with this product may lead to unexpected or prolonged hypoglycemia.
How serious is the interaction between Insulin degludec-liraglutide and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when isocarboxazid is started or stopped, and lower the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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