Drug interactions
Insulin degludec-liraglutide + Levonorgestrel
Severity: Minor
Insulin degludec-liraglutide and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins such as levonorgestrel may reduce glucose tolerance and insulin sensitivity. This could modestly weaken the glucose-lowering effect of insulin degludec and liraglutide, though the effect is generally small with low-dose products.
What this interaction means in plain words
Insulin degludec-liraglutide and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-liraglutide belongs to Endocrine; Levonorgestrel belongs to Endocrine.
Why it happens
Progestin-related reduction in insulin sensitivity opposes the effect of antidiabetic agents.
What to do
Monitor glycemic control when starting or stopping levonorgestrel and adjust antidiabetic doses only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Insulin degludec-liraglutide with Levonorgestrel?
MediHelp rates the interaction as minor. Insulin degludec-liraglutide and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins such as levonorgestrel may reduce glucose tolerance and insulin sensitivity. This could modestly weaken the glucose-lowering effect of insulin degludec and liraglutide, though the effect is generally small with low-dose products.
How serious is the interaction between Insulin degludec-liraglutide and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting or stopping levonorgestrel and adjust antidiabetic doses only if needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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