Drug interactions
Insulin degludec-liraglutide + Lisinopril
Severity: Moderate
Insulin degludec-liraglutide and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and have been linked to a higher risk of hypoglycemia in patients on insulin or other antidiabetics. The risk is greatest early after starting the ACE inhibitor.
What this interaction means in plain words
Insulin degludec-liraglutide and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
ACE inhibition may enhance insulin sensitivity and glucose uptake through increased bradykinin activity, adding to the hypoglycemic effect.
What to do
Monitor blood glucose closely during the first weeks of ACE inhibitor therapy and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Lisinopril?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and have been linked to a higher risk of hypoglycemia in patients on insulin or other antidiabetics. The risk is greatest early after starting the ACE inhibitor.
How serious is the interaction between Insulin degludec-liraglutide and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the first weeks of ACE inhibitor therapy and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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