Drug interactions
Insulin degludec-liraglutide + Pasireotide
Severity: Moderate
Insulin degludec-liraglutide and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide suppresses insulin and incretin secretion and commonly causes hyperglycemia, which can oppose insulin degludec/liraglutide. Glucose can also fall unpredictably when pasireotide is stopped, so insulin needs may change in either direction.
What this interaction means in plain words
Insulin degludec-liraglutide and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Somatostatin receptor agonism reduces insulin, GLP-1 and GIP secretion, altering glucose control and antidiabetic requirements.
What to do
Monitor blood glucose frequently when pasireotide is started, adjusted or stopped. Adjust the insulin degludec dose and add antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Pasireotide?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide suppresses insulin and incretin secretion and commonly causes hyperglycemia, which can oppose insulin degludec/liraglutide. Glucose can also fall unpredictably when pasireotide is stopped, so insulin needs may change in either direction.
How serious is the interaction between Insulin degludec-liraglutide and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when pasireotide is started, adjusted or stopped. Adjust the insulin degludec dose and add antidiabetic therapy as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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