Drug interactions
Insulin degludec-liraglutide + Phenelzine
Severity: Moderate
Insulin degludec-liraglutide and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can lower blood glucose and strengthen the effect of insulin and other antidiabetic drugs. Patients taking insulin degludec-liraglutide with phenelzine may have more frequent or severe hypoglycemia.
What this interaction means in plain words
Insulin degludec-liraglutide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition may enhance insulin secretion or sensitivity, adding to the glucose-lowering effects of the antidiabetic drugs.
What to do
Monitor blood glucose closely when phenelzine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Insulin degludec-liraglutide with Phenelzine?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can lower blood glucose and strengthen the effect of insulin and other antidiabetic drugs. Patients taking insulin degludec-liraglutide with phenelzine may have more frequent or severe hypoglycemia.
How serious is the interaction between Insulin degludec-liraglutide and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when phenelzine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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