Drug interactions
Insulin degludec-liraglutide + Prednisolone
Severity: Moderate
Insulin degludec-liraglutide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids raise blood glucose and can cause marked hyperglycemia, which opposes the effect of insulin degludec-liraglutide. Insulin requirements often rise during steroid treatment and fall again when it is stopped.
What this interaction means in plain words
Insulin degludec-liraglutide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and cause peripheral insulin resistance, opposing the antidiabetic effect.
What to do
Increase blood glucose monitoring and titrate the insulin dose upward during steroid therapy. Reduce the dose again as the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-liraglutide and Prednisolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Insulin degludec-liraglutide with Prednisolone?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids raise blood glucose and can cause marked hyperglycemia, which opposes the effect of insulin degludec-liraglutide. Insulin requirements often rise during steroid treatment and fall again when it is stopped.
How serious is the interaction between Insulin degludec-liraglutide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring and titrate the insulin dose upward during steroid therapy. Reduce the dose again as the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
