Drug interactions
Insulin degludec-liraglutide + Promethazine
Severity: Minor
Insulin degludec-liraglutide and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine, has been associated with changes in blood glucose and may reduce glycemic control in some diabetic patients. The effect is usually small with occasional use.
What this interaction means in plain words
Insulin degludec-liraglutide and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-liraglutide belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Phenothiazine-class effects on insulin sensitivity and secretion may oppose antidiabetic therapy; the mechanism is not well characterized.
What to do
Monitor blood glucose if promethazine is used repeatedly or at high doses. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-liraglutide and Promethazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Promethazine?
MediHelp rates the interaction as minor. Insulin degludec-liraglutide and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine, has been associated with changes in blood glucose and may reduce glycemic control in some diabetic patients. The effect is usually small with occasional use.
How serious is the interaction between Insulin degludec-liraglutide and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if promethazine is used repeatedly or at high doses. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
