Drug interactions
Insulin degludec-liraglutide + Propranolol
Severity: Moderate
Insulin degludec-liraglutide and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can prolong hypoglycemia in insulin-treated patients and mask tremor and tachycardia. It may also impair insulin secretion and cause hyperglycemia.
What this interaction means in plain words
Insulin degludec-liraglutide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade suppresses glycogenolysis and gluconeogenic recovery and hides adrenergic symptoms.
What to do
Monitor blood glucose frequently when starting or changing propranolol. Advise patients that sweating may be the only warning of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Propranolol?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can prolong hypoglycemia in insulin-treated patients and mask tremor and tachycardia. It may also impair insulin secretion and cause hyperglycemia.
How serious is the interaction between Insulin degludec-liraglutide and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting or changing propranolol. Advise patients that sweating may be the only warning of hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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