Drug interactions
Insulin degludec-liraglutide + Somapacitan
Severity: Moderate
Insulin degludec-liraglutide and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and may raise blood glucose. Patients taking insulin degludec and liraglutide may therefore need higher antidiabetic doses after somapacitan is started.
What this interaction means in plain words
Insulin degludec-liraglutide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and increases lipolysis, which counteracts the glucose-lowering drugs.
What to do
Monitor glucose when somapacitan is started or the dose is changed and adjust the antidiabetic regimen as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Somapacitan?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and may raise blood glucose. Patients taking insulin degludec and liraglutide may therefore need higher antidiabetic doses after somapacitan is started.
How serious is the interaction between Insulin degludec-liraglutide and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when somapacitan is started or the dose is changed and adjust the antidiabetic regimen as required.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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